Joachim L. Schultze is Professor for Genomics and Immunoregulation at the Life and Medical Sciences (LIMES) Institute, University of Bonn, Germany, and the Founding Director of the PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn. His research is placed at the interphase between immunology, neurobiology, genomics and computational biology. Most recently, he and his team started to collaborate with Hewlett Packard Enterprise to adapt memory-driven computing for the first time to answer questions of big data in the life and medical sciences. Within the medical sciences, the myeloid cell compartment in health and disease is a major focus of his current research. Some of his recent findings utilizing state of the art single cell technologies include the determination of the multi-dimensional model of macrophage activation, the characterization of the human peripheral blood-based dendritic cell populations, the role of myeloid cells in healthy aging, cellular programming of tissue macrophages during fetal development and human monocytes during birth, but also the role of these cells in Alzheimer, cancer and chronic obstructive pulmonary disease.