The rapid loss of biodiversity and ongoing climate change are also the result of intensive agriculture. At the same time, they jeopardize agriculture and food security. The Leibniz Lab "Systemic Sustainability" brings together relevant knowledge in science and society on this fundamental challenge in order to promote the development and implementation of systemic solutions. The Leibniz Lab addresses this need by integrating scientific findings in the field of "Biodiversity, Climate, Agriculture and Food" and identifying innovations. In pilot areas in different parts of the world, the Lab addresses regional requirements. It links these with global developments in order to understand the complex interrelationships from a holistic perspective and identify appropriate solutions. The Lab acts as a link between the relevant scientific communities and promotes dialogue between science and society. By pooling the expertise of 41 Leibniz research institutions and 11 research clusters it is creating a central knowledge and advice hub on issues relating to biodiversity, climate, agriculture and nutrition.